December 11, 2015 16:00 - 17:30
BSI Central Building 1F Seminar Room
"Mapping global patterns of connectivity in the mammalian brain"
Howard Hughes Medical Institute, Department of Biology, Stanford University
In biology, structure determines function. The wiring patterns of individual neurons (billions in the mammalian brain) underlie how neural circuits process information essential for perception, cognition, memory, and behavior. Recent advances in neuroscience have produced an impressive array of tools to genetically label, anatomically trace, physiologically record, and functionally perturb specific populations of neurons. However, these methods are mostly applicable to studying local circuits of neurons; information about their long-distance connections is lost. A bottleneck in understanding the brain is to decipher the global patterns of neuronal connectivity.
In this talk, I will describe our recent development of viral-genetic tracing tools that enable systematic mapping of input, output, and input–output relationships of specific neuronal types in defined brain regions at the scale of the entire mouse brain. I will use the locus coeruleus norepinephrine neurons and ventral tegmental area dopamine neurons as two examples to illustrate the utility of these methods in deciphering the circuit architecture of these key neuromodulatory systems.
- Open to Public
- Yoshihiro Yoshihara [Yoshihiro Yoshihara, Neurobiology of Synapse ]