RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Events

[BSI DISCOVERY SEMINAR] Dr. Adrian Moore, BSI

“ BSI DISCOVERY SEMINAR SERIES "How Neurons Get Their Branching Shapes" ”

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Date

December 09, 2015 16:00 - 17:00

date changed to Dec.9

Location

BSI Central Building 1F Seminar Room

Abstract

Neuronal dendrite branching is fundamental for building nervous systems. Branch formation is genetically encoded by transcriptional programs to create dendrite arbor morphological diversity for complex neuronal functions. In Drosophila sensory neurons, the transcription factor Abrupt represses branching via an unknown effector pathway. Targeted screening for branching-control effectors identified Centrosomin, the primary centrosome-associated protein for mitotic spindle maturation. Centrosomin repressed dendrite branch formation and was used by Abrupt to simplify arbor branching. Live imaging revealed that Centrosomin localized to the Golgi cis face and that it recruited microtubule nucleation to Golgi outposts for net retrograde microtubule polymerization away from nascent dendrite branches. Removal of Centrosomin enabled the engagement of wee Augmin activity to promote anterograde microtubule growth into the nascent branches, leading to increased branching. The findings reveal that polarized targeting of Centrosomin to Golgi outposts during elaboration of the dendrite arbor creates a local system for guiding microtubule polymerization.

More Detail

Language
English
Admission
Open to Public
Host
Charles Yokoyama
Contact
Name: Charles Yokoyama
Email:
Phone: 91-7211