RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Events

[Forum] Dr. kurt haas, University of British Columbia

“ Experience-driven brain circuit structural and functional refinement ”

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Date

November 26, 2015 14:00 - 15:00

Location

BSI Central Building 1F Seminar Room

Abstract

The spatial arrangement of a neuron’s synapses determines how inputs interact to perform computations, such as through recruitment of nonlinear conductances by spatially clustered activity. However, it remains poorly understood how such functional arrangements arise. We developed a random access microscope able to simultaneously record activity of every excitatory synapse, somatic firing, and dendrite morphology of an individual neuron throughout plasticity-inducing visual training in awake animals. We find that dendrite growth and pruning in the developing retinotectal system of transparent Xenopus tadpoles is regulated by sensory experience in a manner strongly dependent on each neuron’s evoked responses. We identify rules based on local dendritic activity patterns that promote clustering of synaptic inputs with shared tuning and promote processing of the specific stimuli experienced.

More Detail

Language
English
Admission
Open to Public
Host
Tomomi Shimogori [Tomomi Shimogori, Molecular Mechanisms of Thalamus Development ]
Contact
Name: Tomomi Shimogori
Email:
Phone: 91-7267