RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Events

[Journal Club]

“ Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex.Hojjatollah Azadbakht, Laura M. Parkes, Hamied A. Haroon, Mark Augath, Nikos K. Logothetis, Alex de Crespigny, Helen E. D’Arceuil, and Geoffrey J. M. Parker ”

BSI Private Event

Add this Event to My Calendar

iCal Google
Other
Windows Live Calendar Yahoo! Calendar Microsoft Office Outlook Calendar
Email this event information

Print this Event

Date

November 25, 2015 10:00 - 10:30

Abstract

Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function. Validation of this technique is vital, but has proved difficult due to the lack of an adequate gold standard. In this work, the macaque visual system was used as a model as an extensive body of literature of in vivo and postmortem tracer studies has established a detailed understanding of the underlying connections. We performed probabilistic tractography on high angular resolution diffusion imaging data of 2 ex vivo, in vitro macaque brains. Comparisons were made between identified connections at different thresholds of probabilistic connection "strength," and with various tracking optimization strategies previously proposed in the literature, and known connections from the detailed visual system wiring map described by Felleman and Van Essen (1991; FVE91). On average, 74% of connections that were identified by FVE91 were reproduced by performing the most successfully optimized probabilistic diffusion MRI tractography. Further comparison with the results of a more recent tracer study (Markov et al. 2012) suggests that the fidelity of tractography in estimating the presence or absence of interareal connections may be greater than this.

More Detail

Language
English
Admission
BSI Private Event
RIKEN people can also attend this event.
Link
Cerebral Cortex 25:4299-4309(2015)
Host
Keiji TANAKA [Keiji Tanaka, Cognitive Brain Mapping ]