RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Events

[Forum] Dr. Angela Giangrande, IGBMC, Strasbourg France

“ Of glia and blood ”

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Date

December 10, 2015 16:00 - 17:00

Location

BSI Central Building 1F Seminar Room

Abstract

Multipotent precursors are plastic cells that generate different, stable fates at the correct number, place and time, to allow tissue and organ formation. The molecular pathways driving the progression from multipotent precursors toward stable and specific identities remain poorly understood. We have found that the Drosophila glial fate determinant acts as a ‘time-bomb’ by specifically inducing its own extinction once the correct transcriptional program has been stably activated.

  Our ability to respond and adapt to the internal and external environments relies on our nervous and immune systems, through the presence of glia and blood cells. In vertebrates, these two cell types have evolved from different layers and require different molecular cascades. In the simple Drosophila model, however, the same transcription factor controls the two cell populations, opening novel perspectives to understand the bases of nervous system and immune system evolution.

More Detail

Language
English
Admission
Open to Public
Host
Adrian Moore [Adrian Moore, Genetic Control of Neuronal Architecture ]
Contact
Name: Adrian Moore
Email:
Phone: adrianm@brain.riken.jp