RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

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[BSI Special Seminar Series (BSSS)] Professor Anatol Kreitzer, Gladstone Institute of Neurological Disease

“ Fast-Spiking Interneurons Regulate Ensemble Calcium and Striatum-Dependent Learning ”

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Date

October 02, 2017 16:00 - 17:30

Location

BSI Central Building 1F Seminar Room

Abstract

Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells considered essential for regulation of input gain and spike timing. However, their role in learning and network plasticity is less clear. Using optogenetic silencing, we demonstrate that FSIs are the primary source of feed-forward inhibition onto striatal medium spiny projection neurons (MSNs) and tonically inhibit MSN spiking. FSI silencing increased MSN bursting and calcium transients in vivo, highlighting the potential of FSIs to control calcium-dependent plasticity during learning.
In a spatial learning task, FSI silencing increased the overall frequency of calcium transients throughout the task, but reduced the specificity with which calcium transients aligned to individual task events. Consistent with this, ablation of FSIs disrupted the acquisition of striatum-dependent egocentric learning strategies. Together, our data support a model in which feed-forward inhibition from FSIs limits MSN bursting and restricts calcium-dependent synaptic plasticity to behaviorally-relevant ensembles to facilitate efficient learning.

More Detail

Language
English
Admission
Open to Public
Host
Joshua Johansen [Joshua Johansen, Neural Circuitry of Memory ]
Contact
Name: Ohno
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