June 03, 2010 14:00 - 15:00
The discovery of atypical ganglion cell photoreceptors (melanopsin containing intrinsically photosensitive retinal ganglion cells; ipRGCs) in the mammalian retina has greatly advanced our understanding of how light influences several non-image forming visual functions independent of image formation. Some of the non-image forming functions are the adjustment of our internal circadian rhythms to the solar day, which influence our mood, alertness and even learning and memory. We have studied extensively the contribution of outer retinal photoreceptors to the regulation of circadian photoentrainment. We find that rods are the predominant photoreceptor type responsible for circadian photoentrainment from the outer retina, with cones playing a minor role in this function. We further determine how the rod photoreceptors send this information to ipRGCs at different light intensities. Our data reveal an unappreciated role for rods in circadian photoentrainment and determine the retinal circuits of how this response is achieved.
- BSI Private Event
RIKEN people can also attend this event.
- Tomomi Shimogori