RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Events

[BSI Seminar Series (BSS)] Dr. Li-Huei Tsai, Massachusetts Institute of Technology

“ Epigenetic Mechanisms Regulating Memory Formation in Health and Disease ”

Add this Event to My Calendar

iCal Google
Other
Windows Live Calendar Yahoo! Calendar Microsoft Office Outlook Calendar
Email this event information

Print this Event

Date

June 10, 2010 16:00 - 17:30

Location

BSI Ikenohata Building 3F Seminar Room

Abstract

Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. However, effective therapeutic strategies for restoring cognition in these patients are currently lacking. We have been exploring alternative methods that facilitate re-establishment of learning ability and access to long-term memories. Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail acetylation induced by inhibitors of histone deacetylases (HDACis) facilitates learning and memory in wildtype mice as well as in mouse models of disease. We have identified histone deacetylase 2 (HDAC2) to be a major HDAC involved in regulating synaptic plasticity and memory formation. HDAC2-deficient mice exhibit enhanced learning and memory and synaptic plasticity, whereas HDAC2-overexpressing mice exhibit impaired learning and are refractory to the beneficial effects of HDACis in enhancing cognition. We have also been elucidating the role of the class III HDAC SIRT1 in cognition. SIRT1 is highly expressed in the hippocampus, and activation of SIRT1 enhances, while its loss-of-function impairs, synaptic plasticity and learning and memory. SIRT1 activation is also neuroprotective in mouse models of neurodegenerative diseases such as Alzheimer’s disease and ALS. These findings illustrate the strikingly distinct functions of different HDACs in the nervous system. The elucidation of the mechanisms by which these proteins influence synaptic plasticity and memory function will provide druggable targets for the treatment of cognitive decline and neurodegeneration.

More Detail

Language
English
Admission
Open to Public
Link
http://www.brain.riken.jp/en/learning/BSS/index.html
Host
Shigeyoshi Itohara
Contact
Name: Seminar Committee
Email:
Phone: 048-462-1111, Ext. 7521