Faculty Detail / 研究室詳細

Hajime Hirase, Ph.D.

- We focus on how astrocytes can modulate neuronal network activity and vice versa in living rodent brain.

Neuron-Glia Circuitry

Team Leader

In vivo neuron-glia interaction, Cerebral corticalhippocampal microcircuitry

Hajime  Hirase

Research Area

The mammalian brain consists of neurons, glia, and vasculature. Among glial cells, astrocytes provide maintenance of extracellular space and metabolic support to neurons. In addition to the supportive roles of astrocytes, it has been hypothesized that astrocytes actively participate in neural information processing by releasing neurotransmitters such as glutamate and ATP. Although much of cellular and subcellular physiology of neurons and glia has been studied in great detail using in vitro preparations, network dynamics of neuron-glia circuitry remains largely unexplored in in vivo conditions. The overall goal of this laboratory is to investigate neuronal and glial microcircuitry in the neocortex and hippocampus in vivo.

Selected Publications View All

  1. 1

    Oe Y, Baba O, Ashida H, Nakamura KC, and Hirase H: "Glycogen distribution in the microwave-fixed mouse brain reveals heterogeneous astrocytic patterns.", Glia (2016)

  2. 2

    Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, Mikoshiba K, Itohara S, Nakai J, Iwai Y, and Hirase H: "Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.", Nat Commun, 7, 11100 (2016)

  3. 3

    Shinohara Y, Hosoya A, and Hirase H: "Experience enhances gamma oscillations and interhemispheric asymmetry in the hippocampus.", Nat Commun, 4, 1652 (2013)

  4. 4

    Takata N, Nagai T, Ozawa K, Oe Y, Mikoshiba K, and Hirase H: "Cerebral blood flow modulation by Basal forebrain or whisker stimulation can occur independently of large cytosolic ca(2+) signaling in astrocytes.", PLoS One, 8(6), e66525 (2013)

  5. 5

    Shinohara Y, Hosoya A, Yahagi K, Ferecskó AS, Yaguchi K, Sík A, Itakura M, Takahashi M, and Hirase H: "Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents.", Eur J Neurosci (2012)

  6. 6

    Takata N, Mishima T, Hisatsune C, Nagai T, Ebisui E, Mikoshiba K, and Hirase H: "Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo.", J Neurosci, 31(49), 18155-18165 (2011)

  7. 7

    Mishima T, and Hirase H: "In vivo intracellular recording suggests that gray matter astrocytes in mature cerebral cortex and hippocampus are electrophysiologically homogeneous.", J Neurosci, 30(8), 3093-100 (2010)

  8. 8

    Sakatani S, Seto-Ohshima A, Shinohara Y, Yamamoto Y, Yamamoto H, Itohara S, and Hirase H: "Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.", J Neurosci, 28(43), 10928-36 (2008)

  9. 9

    Takata N, and Hirase H: "Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo.", PLoS One, 3(6), e2525 (2008)

  10. 10

    Gulyás AI, Buzsáki G, Freund TF, and Hirase H: "Populations of hippocampal inhibitory neurons express different levels of cytochrome c.", Eur J Neurosci, 23(10), 2581-94 (2006)