Faculty Detail / 研究室詳細

Toshihiko Hosoya, Ph.D.

- The goal of our laboratory is to understand brain functions by investigating local neuronal circuits.

Local Neuronal Circuits

Team Leader

Local neuronal circuit, Information processing, Circuit genetics

Toshihiko  Hosoya

Research Area

The long-term goal of Hosoya Laboratory is to understand brain functions by investigating local neuronal circuits. The group has two strategies: analyzing simple circuits, and decomposing complex circuits into simpler subcircuits. The model system for the first strategy is the vertebrate retina, with which precise analysis of input/output relationship is possible. Results show that the retinal coding rule is adaptively modified according to the correlations in the visual input, and that single neurons encode multiple quantities with precise temporal patterns of spikes. The target of the second strategy is the local circuit of the mammalian neocortex. Novel microstructures have been identified in Hosoya Laboratory using genetic techniques, and functional analyses are now underway.

Selected Publications View All

  1. 1

    Maruoka H, Kubota K, Kurokawa R, Tsuruno S, and Hosoya T: "Periodic organization of a major subtype of pyramidal neurons in neocortical layer V.", J Neurosci, 31(50), 18522-42 (2011)

  2. 2

    Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, Hosoya T, Higashijima S, and Okamoto H: "The habenula is crucial for experience-dependent modification of fear responses in zebrafish.", Nat Neurosci, 13(11), 1354-6 (2010)

  3. 3

    Oizumi M, Ishii T, Ishibashi K, Hosoya T, and Okada M: "Mismatched decoding in the brain.", J Neurosci, 30(13), 4815-26 (2010)

  4. 4

    Lesica NA, Ishii T, Stanley GB, and Hosoya T: "Estimating receptive fields from responses to natural stimuli with asymmetric intensity distributions.", PLoS One, 3(8), e3060 (2008)

  5. 5

    Kaneda M, Ishii T, and Hosoya T: "Pathway-dependent modulation by P2-purinoceptors in the mouse retina.", Eur J Neurosci, 28(1), 128-36 (2008)

  6. 6

    Hosoya T, Baccus SA, and Meister M: "Dynamic predictive coding by the retina.", Nature, 436(7047), 1971-7 (2005)

  7. 7

    Akiyama Y, Hosoya T, Poole AM, and Hotta Y.: "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals.", Proc Natl Acad Sci U S A, 93(25), 14912-6 (1996)

  8. 8

    Hosoya T, Takizawa K, Nitta K, and Hotta Y.: "Glial cells missing: a binary switch between neuronal and glial determination in Drosophila.", Cell, 82(6), 1025-36 (1995)