RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Faculty Detail / 研究室詳細

Kumi O. Kuroda, M.D., Ph.D.

- In support of parent-infant bonding, we aim to elucidate the brain mechanisms of mammalian parenting and attachment.

Affiliative Social Behavior

Unit Leader

Maternal behavior, Attachment, Parent-infant relationship

Kumi O. Kuroda

Research Area

<Research Unit for Affiliative Social Behaviors>
Our research unit aims to elucidate the brain mechanisms responsible for parent-infant bond in mammals. Mammalian infants require intense care to grow up, including nursing (provision of mother's milk), protection, and education. To guarantee survival and well-being of their young, parents are equipped with innate motivation to nurture them. Infants are also born with attachment instincts, including suckling, crying and following their caregivers. These drives are hard-wired in the mammalian brain, and postnatal learning experiences refine these actual behaviors. The family bond experienced in early life forms the foundation of various kinds of affiliative social behaviors in the adult. Our goal is to determine the neural mechanisms that mediate parenting and attachment. As an experimental model, we are currently focusing on the laboratory mouse (Mus musculus), a species of which both parents and even juveniles provide a high level of care toward the young. The strong analytical tools of behavioral genetics and molecular biology are best applicable for this species among mammals. Our methods encompass behavioral assays, brain area mapping, neural circuit analyses, and identification of relevant molecules and intracellular signaling pathways.

Selected Publications View All

  1. 1

    Yoshida S, Esposito G, Ohnishi R, Tsuneoka Y, Okabe S, Kikusui T, Kato T, and Kuroda KO: "Transport Response is a filial-specific behavioral response to maternal carrying in C57BL/6 mice.", Front Zool, 10(1), 50 (2013)

  2. 2

    Esposito G*, Yoshida S*, Ohnishi R, Tsuneoka Y, Rostagno MC, Yokota S, Okabe S, Kamiya K, Hoshino M, Shimizu M, Venuti P, Kikusui T, and and Kato T and Kuroda KO: "Infant calming responses during maternal carrying in humans and mice", Current Biology, 23(9), 739-745 *These two authors contributed equally to this study. (2013)

  3. 3

    Tsuneoka Y, Maruyama T, Yoshida S, Nishimori K, Kato T, Numan M, and Kuroda KO: "Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse.", J Comp Neurol, 521(7), 1633-63 (2013)

  4. 4

    Tachikawa KS, Yoshihara Y, and Kuroda KO: "Behavioral transition from attack to parenting in male mice: a crucial role of the vomeronasal system.", J Neurosci, 33(12), 5120-6 (2013)

  5. 5

    Kuroda KO, and Tsuneoka Y: "Assessing postpartum maternal care, alloparental behavior, and infanticide in mice: with notes on chemosensory influences.", Methods Mol Biol, 1068, 331-47 (2013)

  6. 6

    Esposito G, Yoshida S, Venuti P, and Kuroda KO: "Three lessons from Philip Teitelbaum and their application to studies of motor development in humans and mice.", Behav Brain Res., 231(2), 366-70 (2012)

  7. 7

    Kuroda KO, Tachikawa K, Yoshida S, Tsuneoka Y, and Numan M: "Neuromolecular basis of parental behavior in laboratory mice and rats: with special emphasis on technical issues of using mouse genetics.", Prog Neuropsychopharmacol Biol Psychiatry, 35(5), 1205-31 (2011)

  8. 8

    Kuroda KO, Ornthanalai VG, Kato T, and Murphy NP: "FosB null mutant mice show enhanced methamphetamine neurotoxicity: potential involvement of FosB in intracellular feedback signaling and astroglial function.", Neuropsychopharmacology, 35(3), 641-55 (2010)

  9. 9

    Kuroda KO, Meaney MJ, Uetani N, and Kato T: "Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB.", Brain Res, 1211, 57-71 (2008)

  10. 10

    Kuroda KO, Meaney MJ, Uetani N, Fortin Y, Ponton A, and Kato T: "ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice.", Mol Cell Neurosci, 36(2), 121-31 (2007)

Press Releases View All