Circuit and Behavioral Physiology
Senior Team Leader
Spatial learning, In vivo physiology, Circuit genetics
Understanding how the circuits of the brain interact to guide behavior is a fundamental goal of neuroscience. Our research focuses on the development and application of genetic and physiological tools in the mouse to understand how plasticity and transmission shapes memory in the hippocampal circuit and beyond.
Flourescent immunolabeling of a coronal section from the brain of a POMC-cre mouse. In this line the expression pattern of the Cre recombinase provides a tool to restrict genetic manipulations only to the granule cells of the dentate gyrus region of the hippocamus.
Jones MW, and McHugh TJ: "Updating hippocampal representations: CA2 joins the circuit.", Trends Neurosci, 34(10), 526-35 (2011)
Kamsler A, McHugh TJ, Gerber D, Huang SY, and Tonegawa S: "Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.", Proc Natl Acad Sci U S A, 107(4), 1618-23 (2010)
McHugh TJ, and Tonegawa S: "CA3 NMDA receptors are required for the rapid formation of a salient contextual representation.", Hippocampus, 19(12), 1153-8 (2009)
Nakashiba T, Buhl DL, McHugh TJ, and Tonegawa S: "Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory.", Neuron, 62(6), 781-7 (2009)
Nakashiba T, Young JZ, McHugh TJ, Buhl DL, and Tonegawa S: "Inducible, Reversible Inhibition of Synaptic Transmission Reveals the Role of CA3 Output in Hippocampal Learning and Memory.", Science, 319(5876), 1260-4 (2008)
McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, and Tonegawa S: "Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.", Science, 317(5834), 1994-9 (2007)
McHugh TJ, and Tonegawa S: "Spatial exploration is required for the formation of contextual fear memory.", Behav Neurosci, 121(2), 335-9 (2007)
McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, and Wilson MA.: "Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice.", Cell, 87(7), 1339-49 (1996)