RIKEN's New Research Center for Brain Science: RIKEN CBS Website


Faculty Detail / 研究室詳細

Thomas J. McHugh, Ph.D.

- We use genetics, neurochemistry and in vivo physiology in mice to study the circuits that encode and modulate memory.

Circuit and Behavioral Physiology

Senior Team Leader

Spatial learning, In vivo physiology, Circuit genetics

Thomas J. McHugh

Research Area

Understanding how the circuits of the brain interact to guide behavior is a fundamental goal of neuroscience. Our research focuses on the development and application of genetic and physiological tools in the mouse to understand how plasticity and transmission shapes memory in the hippocampal circuit and beyond.

Flourescent immunolabeling of a coronal section from the brain of a POMC-cre mouse. In this line the expression pattern of the Cre recombinase provides a tool to restrict genetic manipulations only to the granule cells of the dentate gyrus region of the hippocamus.

Selected Publications View All

  1. 1

    Roman Boehringer, Denis Polygalov, Arthur J.Y. Huang, Steven J. Middleton, Vincent Robert, Marie E. Wintzer, Rebecca A. Piskorowski, Vivien Chevaleyre, and Thomas J. McHugh: "Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability", Neuron, 94(3), 642-655.e9 (2017)

  2. 2

    Middleton SJ, and McHugh TJ: "Silencing CA3 disrupts temporal coding in the CA1 ensemble.", Nat Neurosci (2016)

  3. 3

    Yu LM, Polygalov D, Wintzer ME, Chiang MC, and McHugh TJ: "CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations.", eNeuro, 3(1) (2016)

  4. 4

    Chinnakkaruppan A, Wintzer ME, McHugh TJ, and Rosenblum K: "Differential Contribution of Hippocampal Subfields to Components of Associative Taste Learning.", J Neurosci, 34(33), 11007-11015 (2014)

  5. 5

    Wintzer ME, Boehringer R, Polygalov D, and McHugh TJ: "The Hippocampal CA2 Ensemble Is Sensitive to Contextual Change.", J Neurosci, 34(8), 3056-3066 (2014)

  6. 6

    Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Barrera VR, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, and Tonegawa S: "Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion.", Cell (2012)

  7. 7

    Jones MW, and McHugh TJ: "Updating hippocampal representations: CA2 joins the circuit.", Trends Neurosci, 34(10), 526-35 (2011)

  8. 8

    Nakashiba T, Buhl DL, McHugh TJ, and Tonegawa S: "Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory.", Neuron, 62(6), 781-7 (2009)

  9. 9

    Nakashiba T, Young JZ, McHugh TJ, Buhl DL, and Tonegawa S: "Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning.", Science, 319(5867), 1260-4 (2008)

  10. 10

    Tonegawa S, and McHugh TJ: "The ins and outs of hippocampal circuits.", Neuron, 57(2), 175-7 (2008)

  11. 11

    Nakashiba T, Young JZ, McHugh TJ, Buhl DL, and Tonegawa S: "Inducible, Reversible Inhibition of Synaptic Transmission Reveals the Role of CA3 Output in Hippocampal Learning and Memory.", Science, 319(5876), 1260-4 (2008)

  12. 12

    McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, and Tonegawa S: "Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.", Science, 317(5834), 1994-9 (2007)

  13. 13

    McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, and Wilson MA.: "Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice.", Cell, 87(7), 1339-49 (1996)

Press Releases View All