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Faculty Detail / 研究室詳細

Masanori Murayama, Ph.D.

- We focus on the causal relationship between animal behavior and neural activity at the single-cell, micro-circuit and network levels.

Behavioral Neurophysiology

Senior Team Leader

Dendritic activity, Neural circuits, Optical imaging

Masanori  Murayama

Research Area

Little is known about how neurons integrate feedback and feed forward information for animal behavior. To understand it, we focus on the causal relationship between behavior and neural activity at the single-cell, micro-circuit and network levels. We use multidisciplinary techniques including 2-photon microscopy, fiberoptic imaging, macro-brain imaging, optogenetic techniques and electrophysiological recordings, in awake and anesthetized animals. We are also interested in developing new techniques to discover novel neural activities that can be used for understanding brain functions and animal behavior.

Selected Publications View All

  1. 1

    Manita S, Miyakawa H, Kitamura K, and Murayama M: "Dendritic spikes in sensory perception.", Frontiers in Cellular Neuroscience, 11(29) (2017)

  2. 2

    Miyamoto D, Hirai D, Fung CC, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, and Murayama M: "Top-down cortical input during NREM sleep consolidates perceptual memory.", Science, 352(6291):1315-8., 1315-8 (2016)

  3. 3

    Hirasawa N, Yamada K, and Murayama M: "Brief hind paw stimulation is sufficient to induce delayed somatosensory discrimination learning in C57BL/6 mice.", Behav Brain Res, 301, 15 March 2016, 102-109 (2016)

  4. 4

    Suzuki T, and Murayama M: "Craniotomy for cortical voltage-sensitive dye imaging in mice", Bio-protocol, Vol 6, Iss 3, Feb 05, 2016 (2016)

  5. 5

    Miyamoto D, and Murayama M: "The fiber-optic imaging and manipulation of neural activity during animal behavior.", Neurosci Res, 2015 Sep 30. pii: S0168-0102(15)00228-X. (2015)

  6. 6

    Manita S, Suzuki T, Homma C, Matsumoto T, Odagawa M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, and Murayama M.: "A Top-Down Cortical Circuit for Accurate Sensory Perception.", Neuron, 2015 Jun 3;86(5):1304-16. (2015)

  7. 7

    Takekawa T, Ota K, Murayama M, and Fukai T.: "Spike detection from noisy neural data in linear-probe recordings.", Eur J Neurosci., 2014 Jun;39(11):1943-50. (2014)

  8. 8

    Palmer L, Murayama M, and Larkum M: "Inhibitory Regulation of Dendritic Activity in vivo.", Front Neural Circuits, 6, 26 (2012)

  9. 9

    Palmer LM, Schulz JM, Murphy SC, Ledergerber D, Murayama M, and Larkum ME: "The cellular basis of GABA(B)-mediated interhemispheric inhibition.", Science, 335(6071), 989-93 (2012)

  10. 10

    Murayama M, and Larkum M: "Fiber-optic calcium monitoring of dendritic activity in vivo.", Cold Spring Harb Protoc, 2012(2) (2012)

  11. 11

    Lütcke H, Murayama M, Hahn T, Margolis DJ, Astori S, Zum Alten Borgloh SM, Göbel W, Yang Y, Tang W, Kügler S, Sprengel R, Nagai T, Miyawaki A, Larkum ME, Helmchen F, and Hasan MT: "Optical recording of neuronal activity with a genetically-encoded calcium indicator in anesthetized and freely moving mice.", Front Neural Circuits, 4, 9 (2010)

  12. 12

    Murayama M, Pérez-Garci E, Nevian T, Bock T, Senn W, and Larkum ME: "Dendritic encoding of sensory stimuli controlled by deep cortical interneurons.", Nature, 457(7233), 1137-41 (2009)

Press Releases View All