Alexey Semyanov, Ph.D., Dr.Sc.
- We are interested in intercellular communication beyond the synapse.
Extrasynaptic Signaling
Unit Leader
Extrasynaptic signaling, Extrasynaptic plasticity, Neuron-glia communication
We use electrophysiological and imaging techniques to reveal the functions of extrasynaptic interactions in the brain. This involves studying release and uptake of extrasynaptic signalling molecules, their diffusion in the extracellular space, and localisation and properties of their receptors.
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1
Tanaka M, Shih PY, Gomi H, Yoshida T, Nakai J, Ando R, Furuichi T, Mikoshiba K, Semyanov A, and Itohara S: "Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses.", Mol Brain, 6(1), 6 (2013)
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2
Wu YW, Grebenyuk S, McHugh TJ, Rusakov DA, and Semyanov A: "Backpropagating Action Potentials Enable Detection of Extrasynaptic Glutamate by NMDA Receptors.", Cell Rep, 1(5), 495-505 (2012)
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3
Song I, Savtchenko L, and Semyanov A: "Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons.", Nat Commun, 2, 376 (2011)
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4
Rama S, Vetrivel L, and Semyanov A: "Second-harmonic generation voltage imaging at subcellular resolution in rat hippocampal slices.", J Biophotonics, 3(12), 784-90 (2010)
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5
Pavlov I, Savtchenko LP, Kullmann DM, Semyanov A, and Walker MC: "Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain.", J Neurosci, 29(48), 15341-50 (2009)
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6
Semyanov A: "Can diffuse extrasynaptic signaling form a guiding template?", Neurochem Int, 52(1-2), 31-3 (2008)
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7
Semyanov A, Walker MC, Kullmann DM, and Silver RA: "Tonically active GABA A receptors: modulating gain and maintaining the tone.", Trends Neurosci, 27(5), 262-9 (2004)
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8
Semyanov A, Walker MC, and Kullmann DM: "GABA uptake regulates cortical excitability via cell type-specific tonic inhibition.", Nat Neurosci, 6(5), 484-90 (2003)
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9
Semyanov A, and Kullmann DM.: "Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons.", Nat Neurosci, 4(7), 718-23 (2001)
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10
Semyanov A, and Kullmann DM.: "Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors.", Neuron, 25(3), 663-72 (2000)
