Keiji Tanaka, Ph.D.
- Our goal is to reveal mechanisms of higher brain functions such as visual object recognition and goal-directed behavior.
Cognitive Brain Mapping
Senior Team Leader
Visual object recognition, Goal-directed behavior
To reveal mechanisms of higher brain functions such as recognition and decision making, we are conducting experiments with non-human primates and functional MRI with a 4T system on normal human subjects. In the research with non-human primates, the animals are trained with various behavioral paradigms, and effects of functional blocage of particular brain sites or connections are examined and single-cell recordings are conducted during the task performance. We are focusing on the mechanisms of visual object recognition in the inferotemporal cortex and those of goal-directed behavior in the prefrontal cortex. To relate research results in human subjects with those in experimental animals, we are also making efforts to increase the spatial resolution of fMRI with human subjects.
fMRI imaging of the ocular dominance column of the human primary visual cortex. Results of functional imaging are shown by colors on the grey anatomical images. The regions with greater signals during visual stimulation to the left eye than the right-eye stimulation are colored in yellow, and those with greater signals during right-eye stimulation in blue. The results of the first measurement are shown in the upper half, and those of the second measurement in the lower half. The two patterns well overlapped with each other, which proved the reliability of the imaged pattern.
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Mansouri, F. A., Buckley, M. J., Mahboubi, M., Tanaka, and K: "Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices.", Proceeding of National Academy of Science U. S. A., 112: E3940-E3949 (2015)
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2
Wan, X., Cheng, K., Tanaka, and K.: "Neural Encoding of Opposing Strategy Values in Anterior and Posterior Cingulate Cortex.", Nature Neuroscience, 18: 752-759 (2015)
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3
Wan X, Nakatani H, Ueno K, Asamizuya T, Cheng K, and Tanaka K: "The neural basis of intuitive best next-move generation in board game experts.", Science, 331(6015), 341-6 (2011)
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Buckley MJ, Mansouri FA, Hoda H, Mahboubi M, Browning PG, Kwok SC, Phillips A, and Tanaka K: "Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.", Science, 325(5936), 1952-8 (2009)
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Mansouri FA, Buckley MJ, and Tanaka K: "Mnemonic function of the dorsolateral prefrontal cortex in conflict-induced behavioral adjustment.", Science, 318(5852), 987-90 (2007)
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Matsumoto M, Matsumoto K, Abe H, and Tanaka K: "Medial prefrontal cell activity signaling prediction errors of action values.", Nat Neurosci, 10(5), 647-56 (2007)
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Wang, G., Obama, S., Yamashita, W., Sugihara, T., Tanaka, and K.: "View-invariant object recognition without experience of object rotations.", Nature Neuroscience, 8, 1568-1575 (2005)
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Gardner JL, Sun P, Waggoner RA, Ueno K, Tanaka K, and Cheng K: "Contrast adaptation and representation in human early visual cortex.", Neuron, 47(4), 607-20 (2005)
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Matsumoto K, Suzuki W, and Tanaka K: "Neuronal correlates of goal-based motor selection in the prefrontal cortex.", Science, 301(5630), 229-32 (2003)
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10
Cheng K, Waggoner RA, and Tanaka K: "Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging.", Neuron, 32(2), 359-74 (2001)
- Apr. 21, 2015 A “cingular” strategy for attack and defense Keiji Tanaka, Ph.D., Cognitive Brain Mapping
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Jan. 21, 2011
Researchers uncover neural origins of expert intuition
Keiji TANAKA, Ph.D., Cognitive Brain Mapping
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Jul. 3, 2009
Mapping the prefrontal cortex
Keiji TANAKA, Ph.D., Cognitive Brain Mapping, Farshad A. Mansouri, Ph.D., Cognitive Brain Mapping
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Oct. 26, 2007
Damage to a specific brain area impairs the decision process
Keiji TANAKA, Ph.D., Cognitive Brain Mapping
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Oct. 15, 2007
High-resolution brain mapping taken to next level
Kang CHENG, Ph.D., Cognitive Brain Mapping
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Nov. 21, 2005
A New Discovery in the Brain Mechanism Visually Recognizing "Objects"
Keiji TANAKA, Ph.D., Cognitive Brain Mapping
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Jul. 11, 2003
Neuronal Correlates of Goal-Based Motor Selection in the Prefrontal Cortex
Keiji TANAKA, Ph.D., Cognitive Brain Mapping, Kenji MATSUMOTO, Ph.D., Cognitive Brain Mapping
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Oct. 25, 2001
First success in achieving high density imaging of human brain activity: Non-invasive observation of the columnar structure of the cerebral cortex.
Keiji TANAKA, Ph.D., Cognitive Brain Mapping
