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Faculty Detail / 研究室詳細

Motomasa Tanaka, Ph.D.

- We aim to elucidate the mechanism of protein aggregation and its physiological consequences.

Protein Conformation Diseases

Team Leader

Protein misfolding, Amyloid

Motomasa  Tanaka

Research Area

We are investigating the molecular basis of neuropsychiatric diseases using both in vivo and in vitro systems with a variety of techniques including neuroscience, genetics, chemical biology and structural biology. In conjunction, we are seeking to develop novel proteomics or genomics technologies to advance our understanding of the mechanisms of cellular aging and abnormal mRNA translation. Furthermore, we will uncover the structural basis of formation, disaggregation and propagation of amyloid fibers using the yeast prion system that we have established.

Selected Publications View All

  1. 1

    Endo R, Takashima N, Nekooki-Machida Y, Komi Y, Hui KK, Takao M, Akatsu H, Murayama S, Sawa A, and Tanaka M: "DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD.", Biological Psychiatry (2018)

  2. 2

    Chen CW, and Tanaka M: "Genome-Wide Translation Profiling by Ribosome-Bound tRNA Capture.", Cell Reports (2018)

  3. 3

    Ohhashi Y, Yamaguchi Y, Kurahashi H, Kamatari YO, Sugiyama S, Uluca B, Piechatzek T, Komi Y, Shida T, Müller H, Hanashima S, Heise H, Kuwata K, and Tanaka M: "Molecular basis for diversification of yeast prion strain conformation.", Proc. Natl. Acad. Sci. U. S. A., 115(10), 2389-2394 (2018)

  4. 4

    Tanaka M, Ishizuka K, Nekooki-Machida Y, Endo R, Takashima N, Sasaki H, Komi Y, Gathercole A, Huston E, Ishii K, Hui KK, Kurosawa M, Kim SH, Nukina N, Takimoto E, Houslay MD, and Sawa A: "Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.", J Clin Invest, 127, 1438-50 (2017)

  5. 5

    Suzuki G, Weissman JS, and Tanaka M: "[KIL-d] protein element confers antiviral activity via catastrophic viral mutagenesis.", Mol Cell, 60, 651-660 (2015)

  6. 6

    Tanaka M, and Komi Y: "Layers of structure and function in protein aggregation.", Nat Chem Biol, 11, 373-377 (2015)

  7. 7

    Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, and Saido TC: "Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.", Am J Pathol., 185(2), 305-13 (2014)

  8. 8

    Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, and Saido TC: "Aβ secretion and plaque formation depend on autophagy. ", Cell Reports, 5, 61-69 (2013)

  9. 9

    Suzuki G, Shimazu N, and Tanaka M: "A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress.", Science, 336(6079), 355-9 (2012)

  10. 10

    Tanaka M: "Protein misfolding: Tracking a toxic polyQ epitope.", Nat Chem Biol, 7(12), 861-862 (2011)

  11. 11

    Ohhashi Y, Ito K, Toyama BH, Weissman JS, and Tanaka M: "Differences in prion strain conformations result from non-native interactions in a nucleus.", Nat Chem Biol, 6(3), 225-230 (2010)

  12. 12

    Nekooki-Machida Y, Kurosawa M, Nukina N, Ito K, Oda T, and Tanaka M: "Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity.", Proc Natl Acad Sci U S A, 106(24), 9679-84 (2009)

  13. 13

    Tanaka M, Collins SR, Toyama BH, and Weissman JS: "The physical basis of how prion conformations determine strain phenotypes.", Nature, 442(7102), 585-9 (2006)

Press Releases View All