RIKEN BRAIN SCIENCE INSTITUTE (RIKEN BSI)

Faculty Detail / 研究室詳細

Andrea Benucci, Ph.D.

- The goal of our laboratory is to understand the neural basis of sensory perception.

Andrea  Benucci

Research Area

Our laboratory studies the neural basis of sensory processing with a major focus on vision. We are particularly interested in understanding the computational rules used by populations of neurons in the visual cortex to process visual information: how does the coordinated activity of groups of neurons, “talking” among each other via action potentials, produce a visual percept? What are the relevant spatial and temporal scales used to process visual information? To address these questions, we are using as a model system the primary visual cortex of mice trained in behavioural tasks. The experimental tools we are using are based on cutting-edge methods in Optogenetics, optical imaging, and electrode recording. This research provides an ideal test-bed for understanding the neural mechanisms of visual perception and its outcomes have the potential to provide important clinical applications in the field of cortical prosthetic.

Selected Publications View All

  1. 1

    Pisauro MA, Benucci A, and Carandini M: "Local and global contributions to hemodynamic activity in mouse cortex.", J Neurophysiol, Mar 16;00125 [PubMed] (2016)

  2. 2

    Zoccolan D, Cox D, and Benucci A: "What can simple brains teach us about how vision works.", Front Neural Circuits, 9:51, [Full] (2015)

  3. 3

    Madisen L, ...,Benucci A, ..., and Zeng H: "Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.", Neuron, Mar 4;85(5):942-58 [PubMed] (2015)

  4. 4

    Carandini M, Shimaoka D, Rossi LF, Sato TK, Benucci A, and Knöpfel T: "Imaging the awake visual cortex with a genetically encoded voltage indicator.", J Neurosci, Jan 7;35(1):53-63 [PubMed] (2015)

  5. 5

    Schölvinck ML, Saleem AB, Benucci A, Harris KD, and Carandini M: "Cortical state determines global variability and correlations in visual cortex.", J Neurosci, Jan 7;35(1):170-8 [PubMed] (2015)

  6. 6

    Pisauro MA, Dhruv NT, Carandini M, and Benucci A: "Fast hemodynamic responses in the visual cortex of the awake mouse", J. Neurosci., Nov 13;33(46), 18343-51 (2013)

  7. 7

    Benucci A, Saleem AB, and Carandini M.: "Adaptation maintains population homeostasis in primary visual cortex", Nat Neurosci., Jun;16(6), 724-9 (2013)

  8. 8

    Okun M, ..., Benucci A, ..., Carandini M, and Harris K: "Population rate dynamics and multineuron firing patterns in sensory cortex.", J Neurosci, Nov 28; 32(48):17108-19 [PubMed] (2012)

  9. 9

    Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW, Carandini M, Yau KW, Sowden JC, and Ali RR.: "Restoration of vision after transplantation of photoreceptors", Nature, 485(7396), 99-103 (2012)

  10. 10

    Benucci A., Ringach D.L., and Carandini M.: "Coding of stimulus sequences by population responses in visual cortex", Nature Neuroscience, 12(10), 1317-24 (2009)

  11. 11

    Katzner S, Nauhaus I, Benucci A, and et al.: "Local origin of field potentials in visual cortex.", Neuron, 61, 35-41 [PubMed] (2009)

  12. 12

    Nauhaus I, Benucci A, Carandini M, and Ringach DL: "Neuronal selectivity and local map structure in visual cortex.", Neuron, 57:673-679 [PubMed] (2008)

  13. 13

    Benucci A, Verschure PF, and Konig P: "Dynamical features of higher-order correlation events: impact on cortical cells.", Cogn Neurodyn, 1:53-69 [PubMed] (2007)

  14. 14

    Benucci A., Frazor R.A., and Carandini M.: "Standing waves and traveling waves distinguish two circuits in visual cortex", Neuron, 55, 103-117 (2007)

  15. 15

    Benucci A., Verschure P.F., and Konig P.: "High-order events in cortical networks: a lower bound", Phys. Rev. E Stat Nonlin Soft Matter Phys., 70, 051909 (2004)

  16. 16

    Benucci A., Verschure P.F., and Konig P.: "Two-state membrane potential fluctuations driven by weak pairwise correlations", Neural Comput., 16, 2351-2378 (2004)

  17. 17

    Benucci A., Verschure P.F., and Konig P.: "Existence of high-order correlations in cortical activity", Phys. Rev. E Stat Nonlin Soft Matter Phys., 68, 041905 (2003)