RIKEN-MIT Center for Neural Circuit Genetics
Neuroscience / Behavior, Biology / Biochemistry, Molecular Biology / Genetics
Learning and memory are vital for day-to-day living—from finding our way home to playing tennis to giving a cohesive speech. Some of us have personally witnessed the devastating consequences of memory disorders, whether it's the severe inability to form new memories, as seen in Alzheimer's patients, or difficulty in suppressing a recall of a memory of a highly unpleasant experience, as seen in PTSD patients. The main research interest in our laboratory is to decipher brain mechanisms subserving learning and memory.
We seek to understand what happens in the brain when a memory is formed, when a fragile short-term memory is consolidated to a solid long-term memory, and when a memory formed previously is recalled on subsequent occasions.
We also seek to understand the role of memory in decision-making, and how various external or internal factors, such as reward, punishment, attention and the subject's emotional state, affect learning and memory. In summary, we study how the central nervous system in the brain enables our mind, with a focus on learning and memory.
Ramirez S., Liu X., Lin P.A., Suh J., Pignatelli M., Redondo R., Ryan T.J., and Tonegawa S.: "Creating a False Memory in the Hippocampus", Science, 341, 387-391 (2013)
Dragoi D. and Tonegawa S: "Distinct preplay of multiple novel spatial experiences in the rat", PNAS, 110(22), 9100-9105 (2013)
Dolan B.M., Duron S.G., Campbell D.A., Vollrath B., Rao B.S.S., Ko H.Y., Lin G.G., Govindarajan A., Choi S.Y., and Tonegawa S.: "Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486", PNAS, 110(14), 5671-6 (2013)
Liu X., Ramirez S., Pang P., Puryear C., Govindarajan A., Deisseroth K., and Tonegawa S: "Optogenetic stimulation of a hippocampal engram activates fear memory recall", Nature, doi:10.1038/nature11028 (2012)
Nakashiba T., Cushman J., Pelkey K., Renaudineau S., Buhl D., McHugh T.J., Rodriguez Barrera V., Chittajallu R., Iwamoto K.S., McBain C.J., Fanselow M.S., and Tonegawa S.: "Young Dentate Granule Cells Mediate Pattern Separation whereas Old Granule Cells Facilitate Pattern Completion", Cell, 149(1), 188-201 (2012)
Nakazawa K., Quirk M.C., Chitwood R.A., Watanabe M., Yeckel M.F., Sun L.D., Kato A., Carr C.A., Johnston D., Wilson M.A., and Tonegawa S. : "Requirement for hippocampal CA3 NMDA receptors in associative memory recall", Science, 297, 211-218 (2002)
Zeng H., Chattarji S., Barbarosie M., Rondi-Reig L., Philpot B.D., Miyakawa T., Bear M.F., and Tonegawa S.: "Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory", Cell, 107, 617-629 (2001)
Tsien J.Z., Huerta P.T., and Tonegawa S.: "The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory", Cell, 87, 1327-1338 (1996)
Silva A., Paylor R., Wehner J.M., and Tonegawa S: "Impaired Spatial Learning in a Calcium-Calmodulin Kinase II Mutant Mice", Science, 257, 206-211 (1992)
Tonegawa S.: "Somatic Generation of Antibody Diversity", Nature, 302, 575-581 (1983)
- Apr. 24, 2014 Oops! Researchers find neural signature for mistake correction Susumu Tonegawa, M.D., Ph.D., Molecular Dynamics of Mental Disorders
- Jan. 24, 2014 Islands in the brain: new circuit shapes memory formation Susumu Tonegawa, Ph.D., RIKEN-MIT Center for Neural Circuit Genetics
- Oct. 17, 2013 Mice modeling schizophrenia show key brain network in overdrive Susumu Tonegawa, Ph.D., RIKEN-MIT Center for Neural Circuit Genetics
- Jul. 25, 2013 Mice "incepted" with false memories provide insight into neural phenomena Susumu Tonegawa, Ph.D., RIKEN-MIT Center for Neural Circuit Genetics
- Jan. 25, 2008 The technology that intercepts the nerve system and recovers is developed for the first time in the world.- Birth of reformation base technology that solves mechanism of complex nerve system - Susumu TONEGAWA, Ph.D., RIKEN-MIT Neuroscience Research Center
- Feb. 20, 2007 Joint research between Molecular Psychiatry of BSI and the RIKEN-MIT Neuroscience Research Center has identified genes causative to schizophrenia Takeo YOSHIKAWA, M.D., Ph.D., Molecular Psychiatry, Susumu Tonegawa, Ph.D., RIKEN-MIT Center for Neural Circuit Genetics