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Faculty Publications

Thomas J. McHugh

Thomas J. McHugh, Ph.D.

Circuit and Behavioral Physiology / Senior Team Leader

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  1. 1

    Roman Boehringer, Denis Polygalov, Arthur J.Y. Huang, Steven J. Middleton, Vincent Robert, Marie E. Wintzer, Rebecca A. Piskorowski, Vivien Chevaleyre, and Thomas J. McHugh: "Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability", Neuron, 94(3), 642-655.e9 (2017)

  2. 2

    Middleton SJ, and McHugh TJ: "Silencing CA3 disrupts temporal coding in the CA1 ensemble.", Nat Neurosci (2016)

  3. 3

    Yu LM, Polygalov D, Wintzer ME, Chiang MC, and McHugh TJ: "CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations.", eNeuro, 3(1) (2016)

  4. 4

    Roh M, McHugh TJ, and Lee K: "A video based feedback system for control of an active commutator during behavioral physiology.", Mol Brain, 8(1), 61 (2015)

  5. 5

    Tsuneoka Y, Tokita K, Yoshihara C, Amano T, Esposito G, Huang AJ, Yu LM, Odaka Y, Shinozuka K, McHugh TJ, and Kuroda KO: "Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice.", EMBO J (2015)

  6. 6

    Sakaguchi M, Kim K, Yu LM, Hashikawa Y, Sekine Y, Okumura Y, Kawano M, Hayashi M, Kumar D, Boyden ES, McHugh TJ, and Hayashi Y: "Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice.", PLoS One, 10(6), e0130163 (2015)

  7. 7

    Chinnakkaruppan A, Wintzer ME, McHugh TJ, and Rosenblum K: "Differential Contribution of Hippocampal Subfields to Components of Associative Taste Learning.", J Neurosci, 34(33), 11007-11015 (2014)

  8. 8

    Tomar A, Polygalov D, Chattarji S, and McHugh TJ: "The dynamic impact of repeated stress on the hippocampal spatial map.", Hippocampus (2014)

  9. 9

    Wintzer ME, Boehringer R, Polygalov D, and McHugh TJ: "The Hippocampal CA2 Ensemble Is Sensitive to Contextual Change.", J Neurosci, 34(8), 3056-3066 (2014)

  10. 10

    Shih PY, Savtchenko LP, Kamasawa N, Dembitskaya Y, McHugh TJ, Rusakov DA, Shigemoto R, and Semyanov A: "Retrograde Synaptic Signaling Mediated by K+ Efflux through Postsynaptic NMDA Receptors.", Cell Rep (2013)

  11. 11

    Aizawa H, Yanagihara S, Kobayashi M, Niisato K, Takekawa T, Harukuni R, McHugh TJ, Fukai T, Isomura Y, and Okamoto H: "The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation.", J Neurosci, 33(20), 8909-21 (2013)

  12. 12

    Wu YW, Grebenyuk S, McHugh TJ, Rusakov DA, and Semyanov A: "Backpropagating Action Potentials Enable Detection of Extrasynaptic Glutamate by NMDA Receptors.", Cell Rep, 1(5), 495-505 (2012)

  13. 13

    Place R, Lykken C, Beer Z, Suh J, McHugh TJ, Tonegawa S, Eichenbaum H, and Sauvage MM: "NMDA signaling in CA1 mediates selectively the spatial component of episodic memory.", Learn Mem, 19(4), 164-9 (2012)

  14. 14

    Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Barrera VR, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, and Tonegawa S: "Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion.", Cell (2012)

  15. 15

    Jones MW, and McHugh TJ: "Updating hippocampal representations: CA2 joins the circuit.", Trends Neurosci, 34(10), 526-35 (2011)

  16. 16

    Kamsler A, McHugh TJ, Gerber D, Huang SY, and Tonegawa S: "Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.", Proc Natl Acad Sci U S A, 107(4), 1618-23 (2010)

  17. 17

    McHugh TJ, and Tonegawa S: "CA3 NMDA receptors are required for the rapid formation of a salient contextual representation.", Hippocampus, 19(12), 1153-8 (2009)

  18. 18

    Nakashiba T, Buhl DL, McHugh TJ, and Tonegawa S: "Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory.", Neuron, 62(6), 781-7 (2009)

  19. 19

    Nakashiba T, Young JZ, McHugh TJ, Buhl DL, and Tonegawa S: "Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning.", Science, 319(5867), 1260-4 (2008)

  20. 20

    Tonegawa S, and McHugh TJ: "The ins and outs of hippocampal circuits.", Neuron, 57(2), 175-7 (2008)

  21. 21

    Nakashiba T, Young JZ, McHugh TJ, Buhl DL, and Tonegawa S: "Inducible, Reversible Inhibition of Synaptic Transmission Reveals the Role of CA3 Output in Hippocampal Learning and Memory.", Science, 319(5876), 1260-4 (2008)

  22. 22

    McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, and Tonegawa S: "Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.", Science, 317(5834), 1994-9 (2007)

  23. 23

    McHugh TJ, and Tonegawa S: "Spatial exploration is required for the formation of contextual fear memory.", Behav Neurosci, 121(2), 335-9 (2007)

  24. 24

    Nakazawa K, McHugh TJ, Wilson MA, and Tonegawa S: "NMDA receptors, place cells and hippocampal spatial memory.", Nat Rev Neurosci, 5(5), 361-72 (2004)

  25. 25

    McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, and Wilson MA.: "Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice.", Cell, 87(7), 1339-49 (1996)

  26. 26

    Tonegawa S, Tsien JZ, McHugh TJ, Huerta P, Blum KI, and Wilson MA.: "Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning.", Cold Spring Harb Symp Quant Biol, 61, 225-38 (1996)