Experimental observation of long-term memory formation and retrieval in vertebrate brain has long been an elusive goal. Here, Aoki et al. subject zebrafish to a reinforcement learning task and study neuronal activity as it emerges in a specific brain area of the dorsal pallium the following day. The findings highlight advantages of the zebrafish system to study adaptive behavior.
Tazu Aoki, Masae Kinoshita, Ryo Aoki, Masakazu Agetsuma, Hidenori Aizawa, Masako Yamazaki, Mikako Takahoko, Ryunosuke Amo, Akiko Arata, Shin-ichi Higashijima, Takashi Tsuboi and Hitoshi Okamoto. "Imaging of Neural Ensembles for the Retrieval of Learned Behavioral Programs." Neuron, 2013, doi: 10.1016/j.neuron.2013.04.009