July 19, 2017 11:00 - 12:00
BSI Central Building 1F Seminar Room
Spontaneous neural activity as measured with resting state fMRI (rsfMRI) is widely used to infer the brain’s intrinsic functional organization. However, the neurobiological drivers of this phenomenon remain unclear. What are the fundamental neural elements necessary for its establishment? And what are the biological underpinnings of aberrant rsfMRI activity in brain disorders?
Answering these complex questions requires radically new investigational paradigms that transcend current human rsfMRI approaches. Towards this goal, we have recently undertaken the study of spontaneous rsfMRI activity in the laboratory mouse, where genetic determinants and neuronal activity can be controlled with unprecedented specificity.
In this talk I will summarize some key results of this recent line of inquiry, highlighting remarkable correspondences between mouse and human intrinsic neural network organization, including the presence of distributed mouse brain networks that can be related to orthologous human brain systems. I will also show that, like in humans, spontaneous rsfMRI activity in the mouse brain undergoes dynamic reconfiguration into neuro-functionally relevant network states characterized by gradual assembly and disassembly.
Emphasis will also be given to the recent use of this paradigm to probe connectivity in mouse lines harbouring autism-associated mutations, revealing a role of prefrontal connectivity hubs as putative points of vulnerability for aberrant macroscale network activity in neurodevelopmental disorders. I will finally introduce the combined used of chemogenetics and fMRI (“chemo-fMRI”) as a novel investigational platform to causally-probe regional neuronal activity and brainwide activity, enabling to deconstruct the fundamental elements of rsfMRI couplings.
- Open to Public
- Toru Takumi [Toru Takumi, Mental Biology ]
Name: Toru Takumi