RIKEN BRAIN SCIENCE INSTITUTE (理研BSI)

Faculty Detail / 研究室詳細

Andrea, Benucci

研究内容

私たちのチームでは、視覚を中心とした感覚情報の神経情報処理メカニズムの解明、とくに、ニューロンのアセンブリ活動を基盤とした視覚情報処理の計算論的原理の解明を目標に研究を行います。ニューロンがネットワークの中で発火活動によってどのように情報のやりとりをし視覚の認識を生み出しているのか? また、視覚情報処理の基準となる空間あるいは時間的スケールはどのようなものか? これらの問いに答えるため、行動課題中のマウスの一次視覚野の活動を、オプトジェネティックス、光学イメージング、微小電極記録など、最先端の実験技法を用いながら解析していきます。視覚認識メカニズム解明の研究のための理想的な実験系を構築し、また大脳皮質損傷などに対する医療応用をも見据えます。

主な発表論文 全て表示する

  1. 1

    Pisauro MA, Benucci A, and Carandini M: "Local and global contributions to hemodynamic activity in mouse cortex.", J Neurophysiol, Mar 16;00125 [PubMed] (2016)

  2. 2

    Zoccolan D, Cox D, and Benucci A: "What can simple brains teach us about how vision works.", Front Neural Circuits, 9:51, [Full] (2015)

  3. 3

    Madisen L, ...,Benucci A, ..., and Zeng H: "Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.", Neuron, Mar 4;85(5):942-58 [PubMed] (2015)

  4. 4

    Carandini M, Shimaoka D, Rossi LF, Sato TK, Benucci A, and Knöpfel T: "Imaging the awake visual cortex with a genetically encoded voltage indicator.", J Neurosci, Jan 7;35(1):53-63 [PubMed] (2015)

  5. 5

    Schölvinck ML, Saleem AB, Benucci A, Harris KD, and Carandini M: "Cortical state determines global variability and correlations in visual cortex.", J Neurosci, Jan 7;35(1):170-8 [PubMed] (2015)

  6. 6

    Pisauro MA, Dhruv NT, Carandini M, and Benucci A: "Fast hemodynamic responses in the visual cortex of the awake mouse", J. Neurosci., Nov 13;33(46), 18343-51 (2013)

  7. 7

    Benucci A, Saleem AB, and Carandini M.: "Adaptation maintains population homeostasis in primary visual cortex", Nat Neurosci., Jun;16(6), 724-9 (2013)

  8. 8

    Okun M, ..., Benucci A, ..., Carandini M, and Harris K: "Population rate dynamics and multineuron firing patterns in sensory cortex.", J Neurosci, Nov 28; 32(48):17108-19 [PubMed] (2012)

  9. 9

    Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW, Carandini M, Yau KW, Sowden JC, and Ali RR.: "Restoration of vision after transplantation of photoreceptors", Nature, 485(7396), 99-103 (2012)

  10. 10

    Benucci A., Ringach D.L., and Carandini M.: "Coding of stimulus sequences by population responses in visual cortex", Nature Neuroscience, 12(10), 1317-24 (2009)

  11. 11

    Katzner S, Nauhaus I, Benucci A, and et al.: "Local origin of field potentials in visual cortex.", Neuron, 61, 35-41 [PubMed] (2009)

  12. 12

    Nauhaus I, Benucci A, Carandini M, and Ringach DL: "Neuronal selectivity and local map structure in visual cortex.", Neuron, 57:673-679 [PubMed] (2008)

  13. 13

    Benucci A, Verschure PF, and Konig P: "Dynamical features of higher-order correlation events: impact on cortical cells.", Cogn Neurodyn, 1:53-69 [PubMed] (2007)

  14. 14

    Benucci A., Frazor R.A., and Carandini M.: "Standing waves and traveling waves distinguish two circuits in visual cortex", Neuron, 55, 103-117 (2007)

  15. 15

    Benucci A., Verschure P.F., and Konig P.: "High-order events in cortical networks: a lower bound", Phys. Rev. E Stat Nonlin Soft Matter Phys., 70, 051909 (2004)

  16. 16

    Benucci A., Verschure P.F., and Konig P.: "Two-state membrane potential fluctuations driven by weak pairwise correlations", Neural Comput., 16, 2351-2378 (2004)

  17. 17

    Benucci A., Verschure P.F., and Konig P.: "Existence of high-order correlations in cortical activity", Phys. Rev. E Stat Nonlin Soft Matter Phys., 68, 041905 (2003)