Research Scientist
Per Nilsson, Ph.D

Projects
1 Identification of somatostatin receptor subtype involved in regulation of neprilysin.
2 Proteomic analysis of Alheimer's disease mouse models.
details






Project description: Alzheimers disease (AD) is characterized by the pathological accumulation of amyloid-beta (Abeta), especially in hippocampus and cortex, regions important for cognitive function. Neprilysin has been identified as one of the major proteases involved in the degradation of Abeta and plays therefore an important role in the development of AD. Furthermore, the neuropeptide somatostatin has been found to upregulate neprilysin activity through binding to somatostatin receptor. We aim at identifying which somatostatin receptor is involved and the underlying molecular mechanism of neprilysin upregulation. In a second project we are establishing an experimental approach to quantitatively measure the expression levels of the brain proteome of AD mouse models, in order to identify new proteins involved in AD.

Born
1975-07-13
Birth place Sweden
Hobbies
Climbing, hiking, tennis, badminton and playing the piano.
Personal comment
Japanese food is tasty!! Tsukiji DA I SU KI~~!!

Positions

PNS Researcher 2009-04

Post doc Karolinska Institutet, Stockholm, Sweden 2009-02 to 2009-04

Researcher Dept. of Cell and Molecular Biology, Uppsala University, Sweden, 2008-06 to 2009-01


PhD at Dept. of Cell and Molecular Biology, Uppsala University, Sweden 2002-01 to 2008-05

Society
Publications

















1. Saito T., Suemoto T., Brouwers N., Sleegers K., Funamoto S., Mihira M., Matsuba Y., Yamada K., Nilsson P., Takano J., Nishimura M., Iwata N., Van Broeckhoven C., Ihara Y., Saido TC. (2011) Potent amyloidogenicity and pathogenicity of Aβ3. Nat. Neurosci., 14, 1023-1032.

2. Schuster J., Frojmark A-S., Nilsson P., Badhai J.,Virtanen A. and Dahl N. (2010) Ribosomal protein S19 binds to its own mRNA with reduced affinity in Diamond-Blackfan Anemia. Blood Cells, Molecules, & Diseases, 45: 23-28.

3. Nilsson P., Iwata N., Muramatsu SI., Tjernberg LO., Winblad B. and Saido TC. (2010) Gene therapy in Alzheimer's disease -potential for disease modification. J Cell Mol Med. 2010 Feb 16.

4. Murat A. Cevher, Xiaokan Zhang, Sully Fernandez, Sergey Kim, Jorge Baquero, Per Nilsson, Sean Lee, Anders Virtanen, and Frida E. Kleiman. (2010) Nuclear deadenylation/polyadenylation factors regulate 3’ processing in response to DNA damage. EMBO J. Accepted.

5. Henriksson N., Nilsson P., Wu M., Song H. and Virtanen A. (2010) Recognition of adenosine residues by the active site of poly(A)-specific ribonuclease. J Biol Chem. 285:163-70.

6. Wu M*., Nilsson P*., Henriksson N*., Niedzwiecka A., Lim MK., Cheng Z., Kokkoris K., Virtanen A. and Song H. (2009) Structural basis of m(7)GpppG binding to poly(A)-specific ribonuclease. Structure. 17:276-86. *Equal contribution. Featured article.

7. Nilsson P., Henriksson N., Niedzwiecka A., Balatsos NA., Kokkoris K., Eriksson J. and Virtanen A. (2007) A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties. J Biol Chem. 282:32902-11.

8. Nilsson P*. and Virtanen A. (2006) Expression and purification of recombinant poly(A)-specific ribonuclease (PARN). Int J Biol Macromol. 39(1-3):95-9. *Contribution to 3rd competition for young scientist on challenging proteins arranged by GE Healthcare, Paris, France, 2005.

9. Balatsos NA., Nilsson P., Mazza C., Cusack S. and Virtanen A. (2006) Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC). J Biol Chem. 281:4517-22.

10. Martinez J., Ren YG., Nilsson P., Ehrenberg M. and Virtanen A. (2001) The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation. J Biol Chem. 276:27923-9.


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