Marmoset Brain Atlas

Marmosets show human-like social and skilled behaviors that make them a more appropriate model for some studies than mice, rats, or other primates. For these reasons, marmosets are becoming an essential experimental animal model in the study of human neurological diseases. Studies using marmosets have uncovered several interesting brain functions and dysfunctions associated with specific behaviors. However, these behaviors are generally associated with broad brain regions such as the cerebral cortex. These difficulties are due in part to a lack of appropriate maps that precisely define brain structures in marmosets. For example, positron emission tomography and magnetic resonance imaging (MRI) techniques are commonly used to examine brain metabolism in small animals such as mice; therefore precise maps of brain structures will also permit the application of newer technologies to analyze brain functions in marmosets as well.

Marmoset Brain Image

The main purpose of this study is to provide a structural guide that can be used to map brain functions in marmosets. Thus, the precise marmoset brain atlas presented in this study will permit more in depth and higher quality neurological and neuro-behavioral studies. This research is producing a three-dimensional (3D) volume rendered model of the marmoset brain that combines histological and magnetic resonance images. This atlas provides several advantages, including the ability to visualize the surface of the brain from any angle. The atlas also permits virtual cutting of brain sections in any plane and provides stereotaxic coordinates for all sections: beneficial for both experimental surgeries and radiological studies.

3D Degu Brain Image

Novel contributions:

-The 3D volume rendered model was constructed from histological images obtained from Nissl-stained sections that were aligned with MR images.
-Includes hierarchical identification and labeling of brain structures.
-Facilitates radiological stereotaxic coordinates from the volume rendered model.
-Can also be used to assess brain structures in sections that are cut in any plane. Brain structures in coronal, horizontal, and sagittal sections can all be determined from this atlas because all of the main structures are annotated in the volume rendered model